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Copyright ©ERS Journals Ltd 2005
Randomised trial of ambulatory oxygen in oxygen-dependent COPD
1 Centre de Recherche, Centre de Pneumologie, Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l'Université Laval, 2 Service de Pneumologie, Centre Hospitalier Affilié de l'Hôtel-Dieu de Lévis, and 3 Service de Pneumologie, Centre Hospitalier Universitaire de Sherbrooke, Québec, Canada
CORRESPONDENCE: Y. Lacasse, Centre de Pneumologie, Hôpital Laval, 2725 Chemin Ste-Foy, Ste-Foy, Quebec, G1V 4G5, Canada. Fax: 1 4186564762. E-mail: Yves.Lacasse@med.ulaval.ca
Keywords: Chronic obstructive pulmonary disease, exercise, oxygen therapy, quality of life, randomised controlled trial
Received: September 30, 2004
Accepted January 13, 2005
Long-term oxygen therapy may limit a patient's ability to remain active and may be detrimental to the rehabilitation process. This study aimed to determine the effect of ambulatory oxygen on quality of life and exercise capacity in patients with chronic obstructive pulmonary disease fulfilling the usual criteria of long-term oxygen therapy.
In a 1-yr, randomised, three-period, crossover trial, 24 patients (mean age 68 yrs; mean arterial partial pressure of oxygen at rest 7.1 kPa (53 mmHg)) were allocated to one of the six possible sequences generated by three interventions: 1) standard therapy (home oxygen therapy with an oxygen concentrator only); 2) standard therapy plus as-needed ambulatory oxygen; and 3) standard therapy plus ambulatory compressed air. The comparison of ambulatory oxygen versus ambulatory compressed air was double blind. The main outcomes were quality of life (Chronic Respiratory Questionnaire), exercise tolerance (6-min walk test) and daily duration of exposure to oxygen therapy.
The trial was stopped prematurely after an interim analysis. On average, the patients used few ambulatory cylinders (7.5 oxygen cylinders versus 7.4 compressed air cylinders over a 3-month study period). Ambulatory oxygen had no effect on any of the outcomes.
In conclusion, the current results do not support the widespread provision of ambulatory oxygen to patients with oxygen-dependent chronic obstructive pulmonary disease.
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