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Serum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistance

¹ Dept of Medicine, and ² Research Center of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong.

CORRESPONDENCE: M. S-M. Ip, University Dept of Medicine, Queen Mary Hospital, University of Hong Kong, 102, Pokfulam Road, Hong Kong. Fax: 852 28162863. E-mail: msmip{at}hkucc.hku.hk

Keywords: Adipocyte-fatty acid binding protein, obstructive sleep apnoea

Received: May 16, 2008
Accepted October 3, 2008

Obstructive sleep apnoea (OSA) is associated with insulin resistance and metabolic syndrome. There is evidence that adipocyte-fatty acid binding protein (A-FABP) may be involved in the development of cardiometabolic dysfunction. The present authors hypothesise that A-FABP is upregulated in OSA.

A total of 124 males without hypertension, diabetes mellitus, hyperlipidaemia or cardiovascular disease were recruited and underwent polysomnography. Serum A-FABP levels showed significant positive correlations with duration of oxygen desaturation and minimal oxygen saturation, fasting insulin and insulin resistance index by homeostasis model assessment. When subjects were divided into tertiles according to apnoea/hypopnoea index (AHI), serum A-FABP levels were significantly higher in the group with AHI 34.4 events·h^–1 than the groups with AHI 13.2–34.4 events·h^–1 or with AHI <13.2 events·h^–1. Serum A-FABP levels were significantly higher in the AHI 34.4 group than obesity-matched subjects with AHI <34.4 events·h^–1.

Serum adipocyte-fatty acid binding protein levels correlated with obstructive sleep apnoea and insulin resistance, independently of obesity, and were significantly higher in severe obstructive sleep apnoea. Adipocyte-fatty acid binding protein may play a role in obstructive sleep apnoea and metabolic dysfunction.

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